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Your Vote Counts! VAXCYTE, INC. 2022 Annual Meeting Vote by May 31, 2022 8:59 PM PT / 11:59 PM ET VAXCYTE VAXCYTE, INC. 825 INDUSTRIAL ROAD SUITE 300 SAN CARLOS, CA 94070 D79089-P70361 You invested in VAXCYTE, INC. and it's time to vote! You have the right to vote on proposals being presented at the Annual Meeting. This is an important notice regarding the availability of proxy material for the stockholder meeting to be held on June 1, 2022. Get informed before you vote View the Notice and Proxy Statement and Annual Report online OR you can receive a free paper or email copy of the material(s) by requesting prior to May 18, 2022. If you would like to request a copy of the material(s) for this and/or future stockholder meetings, you may (1) visit, (2) call 1-800-579-1639 or (3) send an email to If sending an email, please include your control number (indicated below) in the subject line. Unless requested, you will not otherwise receive a paper or email copy. For complete information and to vote, visit Control # Smartphone users Point your camera here and vote without entering a control number Vote Virtually at the Meeting* June 1, 2022 8:30 AM PT / 11:30 AM ET Virtually at: *Please check the meeting materials for any special requirements for meeting attendance. V1.1 Vote at THIS IS NOT A VOTABLE BALLOT This is an overview of the proposals being presented at the upcoming stockholder meeting and the more complete proxy materials, which contain important information and are available on the internet or by mail. You are encouraged to access and review the proxy materials before voting. Please follow the instructions on the reverse side to vote on these important matters. Board Voting Items Recommends 1. Election of Class II Directors Nominees would serve until the 2025 Annual Meeting of Stockholders and until their successors have been duly elected and qualified, or, if sooner, until the director's death, resignation or removal. Nominees: 01) Peter Hirth, Ph.D. For 02) Heath Lukatch, Ph.D. 2. Approval, on a non-binding, advisory basis, of the compensation of the Company's named executive officers. For 3. Approval, on a non-binding, advisory basis, of the frequency of future non-binding, advisory votes to approve the 1 Year compensation of our named executive officers. 4. Ratification of the appointment of Deloitte & Touche LLP as the Company's independent registered public accounting firm for the fiscal year ending December 31, 2022. For NOTE: Such other business as may properly come before the meeting or any adjournment thereof. Prefer to receive an email instead? While voting on, be sure to click "Sign up for E-delivery".